Why Do Peaks Tail?

Article

LCGC North America

LCGC North AmericaLCGC North America-07-01-2003
Volume 21
Issue 7

John Dolan discusses the causes of peak tailing, how to measure it, preventive measures, and why newer column types are less prone to tailing problems.

External Link - article-62268.pdf

Articles in this issue
Why Do Peaks Tail?
Validation of Impurity Methods, Part I
Analysis of Various Cyanobacterial Toxins by LC–MS
ASTM Subcommittee E13.19 on Chromatography
The Use of Micrometer-Sized Particles in Ultrahigh Pressure Liquid Chromatography
Recent Videos
The Challenges of Characterizing PFAS in the Environment
The Challenges of Characterizing PFAS in the Environment
Inside the Laboratory: The Mead Group at UNC Wilmington and the North Carolina PFAS Testing Network
Inside the Laboratory: The Mead Group at UNC Wilmington and the North Carolina PFAS Testing Network
Exploring Molecular Dynamics: An Interview with Ezgi Gürler of FeMS
Exploring Molecular Dynamics: An Interview with Ezgi Gürler of FeMS
Developing Advanced Fragmentation Schemes: An Interview with Ezgi Gürler of FeMS
Developing Advanced Fragmentation Schemes: An Interview with Ezgi Gürler of FeMS
Jacqueline Hamilton, Diane Turner, and Caroline Gauchotte-Lindsay © Images courtesy of interviewees
Advancing Science Through Diversity: A Conversation with Women in Chromatography, Part 5
Importance of Collaboration
Importance of Collaboration
Evolving Regulatory Landscape
Evolving Regulatory Landscape
Analysis of Nitrosamine Intermediates
Analysis of Nitrosamine Intermediates
Reference Standards
Reference Standards
Addressing Sources, Reformulations, and Upcoming Regulatory Deadlines
Addressing Sources, Reformulations, and Upcoming Regulatory Deadlines
Related Content
Foliage background with a variety of vibrant plant leaves showing a diverse ecosystem and the biodiversity of nature. | Image Credit: © Leigh Prather - stock.adobe.com

Characterizing Plant Polysaccharides Using Size-Exclusion Chromatography

Aaron Acevedo
April 4th 2025
Article

With green chemistry becoming more standardized, Leena Pitkänen of Aalto University analyzed how useful size-exclusion chromatography (SEC) and asymmetric flow field-flow fractionation (AF4) could be in characterizing plant polysaccharides.

Ep. 35: On the Subject of Continuing Education for Spectroscopists

Ep. 35: On the Subject of Continuing Education for Spectroscopists

April 1st 2025
Podcast
Silvia Radenkovic on Her Research and Passion for Scientific Collaboration

Silvia Radenkovic on Her Research and Passion for Scientific Collaboration

Aaron Acevedo
April 3rd 2025
Article
Ep. 34: A Banner Year for Separation Science at Pittcon 2025

Ep. 34: A Banner Year for Separation Science at Pittcon 2025

March 14th 2025
Podcast
Examining the Relationship Between Vitamin D Levels and Functional Values of Athletes’ Hearts with HPLC–MS/MS

Examining the Relationship Between Vitamin D Levels and Functional Values of Athletes’ Hearts with HPLC–MS/MS

John Chasse
April 3rd 2025
Article

Researchers attempted to ascertain the relationship between vitamin D levels in athletes and the structural and functional values of their hearts assessed through electrocardiographic and echocardiographic parameters. Vitamin D levels were measured using high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS).

Investigating the Protective Effects of Frankincense Oil on Wound Healing with GC–MS

Investigating the Protective Effects of Frankincense Oil on Wound Healing with GC–MS

John Chasse
April 2nd 2025
Article

Frankincense essential oil is known for its anti-inflammatory, antioxidant, and therapeutic properties. A recent study investigated the protective effects of the oil in an excision wound model in rats, focusing on oxidative stress reduction, inflammatory cytokine modulation, and caspase-3 regulation; chemical composition of the oil was analyzed using gas chromatography–mass spectrometry (GC–MS).