Vol 20 No 11 The Column November 2024 Europe PDF

Click here to download the North America PDF of The Column November 2024 issue.

Peng Che fom Vrije Universiteit Amsterdam in the Netherlands discusses the benefits of hyphenating liquid chromatography (LC) with electron activated dissociation mass spectrometry (EAD-MS) to analyze cathinone positional isomers.

Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.

A recent study examined the impurity profile of thirteen different lots of synthetic nicotine and compared them to fourteen lots of nicotine extracted from plants using in-house analytical methods, with samples tested for alkaloids and phenols with reversed-phase high-performance liquid chromatography (RP-HPLC).

A look at the practical benefits of using TIMS-TOF MS in spatial biology applications.