Postnova Announces Viral Collaboration with University of Helsinki
Postnova Analytics has announced a joint collaboration with the Department of Biosciences at the University of Helsinki in Finland, to use AF4 for the purification of halophilic viruses.
Postnova Analytics (Landsberg am Lech, Germany) has announced a joint collaboration with the Department of Biosciences at the University of Helsinki in Finland, to use asymmetrical flow fieldâflow fractionation (AF4) for the purification of halophilic viruses.
Viruses that persist in extreme environments, such as high salinity or high temperatures, are of particular interest to researchers because of their unique adaptations for survival, and one of the main challenges involved in studying these viruses has been to identify an efficient separation technique-in particular, a separation technique that both purifies and maintains the infectious nature of the viruses.
A recent publication to come out of the collaboration details the technique developed to purify and study extremophilic viruses (1). Four viral morphotypes were successfully purified with high virus recoveries and purities comparable to those of multistep ultracentrifugation purification methods. The paper also explains how to use AF4 as a rapid monitoring tool for virus production in slowly growing host cells living in extreme conditions.
For more information, please visit www.postnova.com
Reference
- K. Eskelin et al., Extremophiles21, 1119 (2017).
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
