Overcoming Compound Volatility with Sub-ambient ELSD
The success of evaporative light scattering detection relies on evaporating the eluent without destroying the analyte particle. Where the analyte is non-volatile, evaporator temperatures of 50-100 °C can be used without compound degradation, thus giving maximum sensitivity. However, when compounds have high vapor pressures and the eluent has a high boiling point (e.g. water), detection of semi-volatile compounds is problematic, because the evaporation temperature needs to be set at 30 °C or above in order to evaporate the solvent.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
Axcend Focus LC® Cartridge Options
December 19th 2024Welcome to our comprehensive selection of High-Performance Liquid Chromatography (HPLC) cartridges. Designed for precision and reliability, our cartridges cater to diverse analytical needs, ensuring optimal performance in your laboratory processes.
