Mixed-Mode Cleanup Technique for Drug in Meat Products
Researchers from the Technical University of Denmark and (Lyngby, Denmark) and the Danish Meat Research Institute (Roskilde, Denmark) used a mixed-mode reversed phase?anion exchange cleanup method followed by LC-MS with electrospray ionization time-of-flight detection to analyze mycophenolic acid in dry-cured ham, fermented sausage, and liver pate.
Researchers from the Technical University of Denmark and (Lyngby, Denmark) and the Danish Meat Research Institute (Roskilde, Denmark) used a mixed-mode reversed phase–anion exchange cleanup method followed by LC-MS with electrospray ionization time-of-flight detection to analyze mycophenolic acid in dry-cured ham, fermented sausage, and liver pate. The mycophenolic acid, a compound used an immunosuppressant in organ transplantation, was first extracted from the meat with a bicarbonate–acetonitrile solution.
Study Explores Thin-Film Extraction of Biogenic Amines via HPLC-MS/MS
March 27th 2025Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.
Multi-Step Preparative LC–MS Workflow for Peptide Purification
March 21st 2025This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.
