Michael W. Dong Joins LCGC's Edtorial Advisory Board
LCGC Magazine is pleased to announce the addition of Michael W. Dong, PhD, to its editorial advisory board.
LCGC
Magazine is pleased to announce the addition of Michael W. Dong, PhD, to its editorial advisory board.
Dong is a senior scientist in the Small Molecule Drug Discovery group at Genentech (South San Francisco, CA), a position he has held since 2007. He formerly served as a research director at Synomics Pharma (Wareham, MA), a research fellow at Purdue Pharma (Cranbury, NJ), a senior staff scientist at Applied Biosystems/PerkinElmer (Foster City, CA), and a section head in Hoechst Celanese (Bridgewater, NJ).
Don has conducted training courses at national meetings (ACS, Pittcon, EAS AAPS, HPLC) on High Performance Liquid Chromatography (HPLC) in pharmaceutical analysis and Drug Metabolism and Pharmacokinetics, HPLC method development, ultra high-pressure LC, the drug development process for scientists, and drug quality. His publishing credentials include more than 80 publications in chromatography and analytical chemistry. He has authored a bestseller in chromatography, Modern HPLC for Practicing Scientists (Wiley, 2006) and co-edited Handbook of Pharmaceutical Analysis by HPLC (Elsevier/Academic Press, 2005).
Dong received his doctorate in analytical chemistry from the City University of New York, and a certificate in biotechnology from the University of California, Santa Cruz.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
