Market Trends & Analysis: Ion Chromatography

Ronald Piervincenzi, chief executive officer of the United States Pharmacoepia, focused on how collaboration and component quality can improve worldwide pharmaceutical production standards during a lecture at the Eastern Analytical Symposium (EAS) last month.

This installment of Tips & Tricks focuses on the determination of the molar mass using a light scattering detector as an absolute detection method.

During EAS 2024, Jay Sheffer, a Product Specialist at Metrohm USA, discussed how combustion ion chromatography (CIC) can help address PFAS’ impact on the environment.

The method of standard additions (MoSA) enables quantification of volatile impurities in condensed-phase samples, such as emulsions, for which matrix-matched calibration standards are required. The technique is, however, expensive because it requires multiple analyses of each sample.

This article will discuss an ion-pair reversed-phase liquid chromatography mass spectrometry (IP-RPLC–MS) workflow for the characterization of three messenger RNA (mRNA) key critical quality attributes: 5’ Cap, ORF, and poly(A) tail.