Liquid-Liquid Microextraction of Haloacetic Acids in Drinking Water
Researchers from the University of Córdoba (Córdoba, Spain) studied the use of simultaneous liquid-liquid microextraction and methylation along with headspace gas chromatography-mass spectrometry to determine nine haloacetic acids in drinking water.
Researchers from the University of Córdoba (Córdoba, Spain) studied the use of simultaneous liquid-liquid microextraction and methylation along with headspace gas chromatography-mass spectrometry to determine nine haloacetic acids in drinking water. They methylated the haloacetic acids in a two-phase n-pentane–water system with tetrabutylammonium salt as the phase transfer catalyst. Dimethylsulfate derivatization was accomplished in 3 min with shaking at room temperature. The method provided detection limits of 0.02–0.4 µg/L.
Study Explores Thin-Film Extraction of Biogenic Amines via HPLC-MS/MS
March 27th 2025Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.
Multi-Step Preparative LC–MS Workflow for Peptide Purification
March 21st 2025This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.
