Liquid-Liquid-Liquid Microextraction of Nerve Agents
Researchers from Vertox Laboratory, Defence Research and Development Establishment (Gwalior, India) used a liquid-liquid-liquid microextraction technique followed by liquid chromatography?mass spectrometry (LC?MS) to examine alkyl alkylphosphonic acids, which are important environmental markers of nerve agents.
Researchers from Vertox Laboratory, Defence Research and Development Establishment (Gwalior, India) used a liquid-liquid-liquid microextraction technique followed by liquid chromatography–mass spectrometry (LC–MS) to examine alkyl alkylphosphonic acids, which are important environmental markers of nerve agents. In their technique, the acids were extracted froman acidified aqueous phase to an organic phase located in the pores of a hollow fiber. They were then back extracted into an alkaline acceptor phase in the lumen of the fiber. The researchers validated the method and then applied it to detection of the acids in a water sample provided by the Organization for Prohibition of Chemical Weapons during a proficiency test.
Thermodynamic Insights into Organic Solvent Extraction for Chemical Analysis of Medical Devices
April 16th 2025A new study, published by a researcher from Chemical Characterization Solutions in Minnesota, explored a new approach for sample preparation for the chemical characterization of medical devices.
Study Explores Thin-Film Extraction of Biogenic Amines via HPLC-MS/MS
March 27th 2025Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.
Multi-Step Preparative LC–MS Workflow for Peptide Purification
March 21st 2025This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.
