In-line Reactions in Capillary Electrophoresis: A Typical Application
Capillary electrophoresis (CE) is a small-scale separation technique based on differences in migration speed of species or compounds in an externally applied electric field.
Capillary electrophoresis (CE) is a small-scale separation technique based on differences in migration speed of species or compounds in an externally applied electric field. The separation takes place inside a capillary of which the internal diameter is typically situated between 50 and 100 µm. It is a very versatile technique with possible applications in a variety of fields. This editorial piece highlights one particular application that shows the potential of CE in monitoring or performing reactions. CE is not only used to analyse and follow-up enzymatic or chemical reactions in an off-line mode; the reaction can also be performed inside the capillary (i.e., in-line, whereby the reaction products formed are analysed in the same capillary). In this way, an integrated set-up is obtained which allows a higher degree of automation in analytical systems.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
2024 EAS Awardees Showcase Innovative Research in Analytical Science
November 20th 2024Scientists from the Massachusetts Institute of Technology, the University of Washington, and other leading institutions took the stage at the Eastern Analytical Symposium to accept awards and share insights into their research.
