Dynamic Liquid-Phase Extraction of Anti-Inflammatory Drugs in Urine

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Researchers at the University of Cordoba (Cordoba, Spain) used dynamic liquid-phase microextraction with an ionic liquid as the acceptor phase to extract six nonsteroidal anti-inflammatory drugs from human urine samples.

Researchers at the University of Cordoba (Cordoba, Spain) used dynamic liquid-phase microextraction with an ionic liquid as the acceptor phase to extract six nonsteroidal anti-inflammatory drugs from human urine samples. The extractant liquid was 1-butyl-3-methylimidazolium hexafluorophosphate. The researchers achieved limits of detection ranging from 38 ng/mL to 70 ng/mL and repeatabilities ranging from 2.1% to 3.8%. The analytical method was optimized with respect to chemical, physical, and hydrodynamic variables. The method was found to be useful for drugs in urine in the concentration range 0.1?10 g/mL.

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