Diamond-Based SPE Phases
Scientists from Brigham Young University (Provo, Utah) and US Synthetic Corporation (Orem, Utah) developed C18, C8, and perfluorinated diamond-based reversed-phase solid-phase extraction (SPE) media.
Scientists from Brigham Young University (Provo, Utah) and US Synthetic Corporation (Orem, Utah) developed C18, C8, and perfluorinated diamond-based reversed-phase solid-phase extraction (SPE) media. They examined alkyl chain functionalization, synthesis of the three phases, percent surface coverage, and column reusability, and the C18 phase was tested for stability, percent recovery, and column capacity. The results reportedly showed that the functionalized diamond phases do not have the same limitations as traditional silica-based SPE phases.
Study Explores Thin-Film Extraction of Biogenic Amines via HPLC-MS/MS
March 27th 2025Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.
Multi-Step Preparative LC–MS Workflow for Peptide Purification
March 21st 2025This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.
