Christie Hunt, Director of Proteomics Applications at AB Sciex (Massachusetts, USA), has won the Human Proteome Organization (HPO) 2013 Science and Technology Award.
Christie Hunt, Director of Proteomics Applications at AB Sciex (Massachusetts, USA), has won the Human Proteome Organization (HPO) 2013 Science and Technology Award. Hunt was selected for her contributions to the development and commercialization of a new approach to targeted proteomics, multiple reaction monitoring (MRM)-triggered tandem mass spectrometry (MS).
Hunter worked in collaboration with Leigh Anderson, founder of the Plasma Proteome Institute and head of SISCAPA Assay Technologies, to develop a workflow that used MRM for the quantification of proteins and peptides in plasma by MS. The method has since been widely adopted and named as “Method of the Year” by Nature Methods.
Dave Hicks, Vice President and General Manager of the Pharmaceutical and Academic Business at AB Sciex, said: “We congratulate Dr Christie Hunter on receiving such a prestigious award from HUPO in recognition of her significant contributions to the rise of targeted proteomics as a viable technique to advance biomarker research.”
For more information please visit:
www.absciex.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.