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While comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC×GC-MS) is a powerful analytical technique, the complexity and volume of data generated pose significant challenges for data processing and interpretation, limiting a broader adoption. To overcome this, a recent paper in Briefings in Bioinformatics presented GcDUO, an open-source software designed specifically for the processing and analysis of this data.

Hydrophilic interaction liquid chromatography (HILIC) has emerged as a promising alternative to traditional ion-pair reversed phase liquid chromatography (IP-RPLC) methods for separating oligonucleotides (ON). This work investigates the application of HILIC to the separation of ON sequence and length variants, duplexes, and single-stranded components.

In the third part of Nicholas Snow's series on splitless GC injections, he discusses techniques for setting up the inlet and connections for optimized injections.

The “matrix effect” is one of the sticky details that can make the use of liquid chromatography (LC) for quantitative purposes challenging, even though it is conceptually quite straightforward. In this installment of LC Troubleshooting, Dwight Stoll reviews what is being referred to during talks about “matrix effects”, and discusses some of the potential origins of the phenomenon in practice.

Click here to access the LCGC International March 2025 Europe PDF in an interactive format.

Click here to access the LCGC International March 2025 North America PDF in an interactive format.

Because PFAS is a hot topic, LCGC International will be releasing a video series about it, which will feature numerous North Carolina researchers. We preview this video series here.

A joint study conducted by the University of Modena and Reggio Emilia (Modena, Italy) and the University of Genoa (Genoa, Italy) aimed to optimize a liquid chromatography mass spectrometry (LC-MS) method using a zwitterionic phosphorylcholine hydrophilic interaction liquid chromatography (HILIC) column for detecting persistent and mobile organic contaminants (PMOCs) in wastewater. LCGC International spoke to researchers Caterina Durante (corresponding author of the piece) and Samuele Pellacani about their method and the results yielded.

Here is some of the most popular content posted on LCGC International this week.

The conference theme this year focused on collaboration, connection, and cultivation of the next generation of researchers.

Comprehensive information was derived through the utilization of a QuEChERS-UHPLC–MS/MS and GC–MS/MS method for the detection of 211 volatile and stable pesticide residues in 90 date fruit samples.

In this video interview from Pittcon, Elham "Elle" Akbari sat down with LCGC International to discuss her research, as well as the challenges of using liquid chromatography–mass spectrometry (LC–MS) and combustion ion chromatography (CIC) to characterize PFAS in environmental samples.

Researchers from Stanford University’s School of Medicine and Stanford Health Care report the development of a liquid chromatography high-resolution mass spectrometry (LC–HRMS) method for identifying hemoglobin (Hb) variants. The method can effectively separate several pairs of normal and variant Hb subunits with mass shifts of less than 1 Da and accurately identify them in intact-protein and top-down analyses.

At Pittcon 2025, Long Luo of the University of Utah sat down with LCGC International to discuss his laboratory's tetrahedron approach to their research.

Several sessions at Pittcon 2025 highlighted the importance of mentoring the next generation of analytical scientists in chromatography and spectroscopy. But what concrete actions can truly make a difference?

LCGC International sat down with Su to discuss what winning the Young Investigators in Separation Science Award means for him and his research. Su also passed along some advice for separation scientists and young professionals in this space.

A study investigating the presence of melamine contamination in commercial citrus juices conducted quantification of melamine concentrations in triplicate utilizing a high performance liquid chromatography (HPLC) system.

In the final section of our interview with Christopher Pohl, he imparts knowledge to the next generation of aspiring separation scientists.

In this interview segment, we sat down with Chris Palmer of the University of Montana to discuss his talk, as well as the evolving role of electrokinetic chromatography in applications areas such as environmental analysis.

The company announced multiple new product releases including a series of compact gas chromatography systems, three UV-Vis spectrophotometers, a new line of triple quadrupole mass spectrometers, and more.

In this interview clip, Katelynn Perrault Uptmor, an assistant professor of chemistry at the College of William & Mary, in Williamsburg, Virginia, discusses winning the Emerging Leader in Chromatography Award and her upcoming talk tomorrow.

This morning at Pittcon, The Chromatography Forum of Delaware Valley (CFDV) held an award session for the late Terry Berger, who was this year’s recipient of the Del Nogare Award.

Cato T. Laurencin, MD, PhD, who is well-known as a scientist and entrepreneur with an extensive career in regenerative engineering, delivered the Wallace H. Coulter lecture yesterday. Here are some of the highlights from the talk.

Elham Akbari has been named the recipient of Metrohm USA’s 2025 Young Chemist Award for her work with thermal degradation, as a promising solution for breaking per- and polyfluoroalkyl substances (PFAS), often referred to as "forever chemicals," into less harmful substances. LCGC International spoke to Akbari about her work prior to her presenting her award-winning research at this week’s Pittcon 2025 meeting.

In this penultimate section of our interview with Christopher Pohl, he reflects on the history of chromatography, sharing what he deems the most important moments in the field.

Here is some of the most popular content posted on LCGC International this week.

Each year, LCGC International presents two awards at Pittcon to the winner of the Lifetime Achievement in Chromatography Award and the Emerging Leader in Chromatography Award. This year, Christopher Pohl is the recipient of the Lifetime Achievement Award and Katelynn Perrault Uptmor is the recipient of the Emerging Leader award. The award presentation, which will honor Pohl and Perrault Uptmor, will take place on Tuesday March 4th from 8:30–11:40 am.

In this third part of our interview with Christopher Pohl, he tells us about his most treasured accomplishments from throughout his storied career.

Here, you’ll find an overview of some of the networking opportunities throughout the week that are available for attendees.

In this second part of our interview with Christopher Pohl, we learn about the mentors Pohl turned to throughout his career, and the important teachings he took from them.