July 2000

This month's "Column Watch" describes moving bed chromatography and how the concept is realized in the form of simulated moving bed chromatography. Also included is an inside look at instrumentation, method development, and applications for industrial purifications.

How can internal LC surfaces be made less reactive?

This month's installment of "CE Currents" deals with problems that may arise when using capillary electrophoresis for unattended, long-term operation, such as sample carryover, evaporation effects, capillary conditioning, capillary surface changes, buffer handling, capillary breakage, and detector lamp deterioration.

This installment of "Milestones in Chromatography" looks at two major international meetings held in Las Vegas, Nevada, and Seattle, Washington, that were pivotal in the early development of HPLC.

This month's "Directions in Discovery" gives a brief overview of turbulent- flow liquid chromatography, a technique for fast separations. Two examples demonstrate the use of the technology for high-throughput bioanalytical separations in drug discovery.

The author configured a purge-and-trap GC-MS system that simultaneously improved chromatographic resolution and reduced analysis time.