January 2022

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Gear and wrench by a computer

But Why Doesn’t It Get Better? Kinetic Plots for Liquid Chromatography, Part I: Basic Concepts

Ken Broeckhoven;Dwight R. Stoll
January 1st 2022
ArticleColumn: LC Troubleshooting

Kinetic plots can help us understand how different combinations of parameters will perform in relation the time needed to acquire a particular column efficiency—and thus resolution.

sample preparation visual

The QuEChERSER Mega-Method

Steven J. Lehotay
January 1st 2022
ArticleColumn: Sample Prep Perspectives

QuEChERS has been updated to suit modern instrumentation. Now also “efficient and robust,” QuEChERSER is a “mega-method” that covers a wider polarity range.

gas chromatography in a laboratory

Is Golay’s Famous Equation for HETP Still Relevant in Capillary Gas Chromatography? Part 1: A Common View of HETP

Nicholas H. Snow
January 1st 2022
ArticleColumn: GC Connections

We are all familiar with Golay’s equation relating to height equivalent to a theoretical plate (HETP) in GC. But do we understand it correctly?

colorful monoclonal antibodies

Two-Dimensional Liquid Chromatography (2D-LC): Analysis of Size-Based Heterogeneities in Monoclonal Antibody–Based Biotherapeutic Products

Anurag S. Rathore;Jared Auclair;Sanghati Bhattacharya;Deepika Sarin
January 1st 2022
ArticleColumn: Focus on Biopharmaceutical Analysis

We review different approaches and coupling strategies for analyzing monoclonal antibody aggregates with 2D-LC.

cannabis leaves

Analyzing Trends of the Cannabis Testing Market

Jonathan Edelman
January 1st 2022
ArticleViewpoints

Given the excitement surrounding the “green rush,” it is worth stepping back to examine the trends and nuances of the cannabis testing environment.

Exploring the Implementation of Compact Chromatographic Instrumentation in Common Analytical Workflows

Exploring the Implementation of Compact Chromatographic Instrumentation in Common Analytical Workflows

Sangeeta Kurre;Samuel W. Foster;Kyle Morrow;Alexis Zimmer;Mita Ray;Leah Notarfrancesco;Keyur Patel;James P. Grinias
January 1st 2022
ArticleFeatured Article

Compact instrumentation offers important advantages for many workflows, as illustrated by these examples.

Acid-Catalyzed Isomerization of Carbonyls-2,4- dinitrophenylhydrazone in Mainstream Smoke of Heat-Not-Burn Tobacco Product for HPLC Analysis

Acid-Catalyzed Isomerization of Carbonyls-2,4- dinitrophenylhydrazone in Mainstream Smoke of Heat-Not-Burn Tobacco Product for HPLC Analysis

Hongfei Zhang;Fengpeng Zhu;Chao Chen;Xiangyu Li;Yanbo Luo;Xingyi Jiang;Yongqiang Pang;Wenliang Zhang;Hongwei Hou;Qingyuan Hu
January 1st 2022
ArticlePeer-Reviewed Article

Errors arising from the DNPH approach commonly used to analyze carbonyl compounds in smoke from heat-not-burn (HNB) tobacco can be avoided by using the approach described in this study.