March 2022

With the substantial developments carried out over the past years in instrumentation, columns, and detector hyphenation, the interest in chiral supercritical fluid chromatography (SFC) has been steadily growing in various fields. In the first part of this review article, the theoretical advantages, technological developments, and common practices in chiral SFC are discussed.

A kinetic plot is a powerful tool, but how do you construct one—from either experimental data or data from other sources? We explain.

We review the processes that happen in the inlet when a sample is injected and use this to make some sense of the many available inlet liner configurations.

This month we’ll take a look at Quick Polar Pesticides (QuPPe), comparing and contrasting it with QuEChERS and noting how we can learn from previously developed methods as we strive for improvements.