Immunosorbents for Selective Sample Preparation of Complex Mixtures
January 1st 2008Selective sample preparation techniques are particularly attractive for the analysis of trace amounts of small molecules in complex matrices. In this month's instalment, columnist Ron Majors covers the field of immunoextraction, a technique that employs immobilized antibodies to selectively capture specific analytes using molecular recognition via antibody–antigen interactions. Recently, the introduction of commercial products for specific high-volume environmental and food safety applications should spur further applications of this technique.
The Effect of Modifier on Selectivity in Reversed-Phase High Performance Liquid Chromatography
January 1st 2008The retention behaviour of several compounds has been compared for their selectivity using reversed-phase high performance liquid chromatography with binary water mobile phases composed of methanol, acetonitrile or tetrahydrofuran as modifiers.