January 2021

A focus on untargeted UHPLC–MS/MS lipidomics with data independent acquisition using SWATH technology. This article explores the wide-ranging potential and peculiarities of SWATH–MS hyphenated with UHPLC for the profiling of lipidomes of various biological samples.

LCGC Europe spoke to Yada Nolvachai about a new approach that offers “super-resolution” for comprehensive two‑dimensional gas chromatography (GC×GC) methods.

Sometimes our approach to troubleshooting specific problems has to change in response to changes in high performance liquid chromatography (HPLC) technology over time. In this installment, we discuss changes in technologies for mobile-phase degassing, silica-based stationary phases, and models for reversed-phase selectivity.

Many chromatographic methods are automatically performed by today’s data systems, yet trace their origins to early, simpler techniques. This piece discusses how our data systems both assist and hinder in obtaining maximum information from chromatograms.

Temperature impacts solubility, diffusion, surface tension, and more. It can potentially lead to solute decomposition. This month we will explore the role of temperature in analytical extractions.