Wolfgang Esser-Skala is a postdoctoral researcher at the Christian Doppler Laboratory for Innovative Tools for Biosimilar Characterization at the University of Salzburg, Austria. He primarily develops algorithms and workflows for analyzing mass spectrometric data on post-translational modifications found in biopharmaceuticals.
In Search of The Needle in The Mariana Trench: Host Cell Proteins and the Problem of Dynamic Range
October 9th 2020This article explores the analytical challenges associated with HCP monitoring and reviews recent advances in HCP characterization, with special emphasis on high performance liquid chromatography mass spectrometry (HPLC–MS)-based methods and HCP enrichment techniques.