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Laila Kott

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Articles

Analysis of Boronic Compounds as Potential Mutagenic Impurities in Drug Substances By GC–MS

Analysis of Boronic Compounds as Potential Mutagenic Impurities in Drug Substances By GC–MS

Zhisong Ji;Jelena Petrovic;Laila Kott
December 1st 2021

This novel gas chromatography (GC)–MS approach enables analysis of the suspected mutagens bis(pinacolato)diboron (BPD) and tetrahydroxydiboron (BBA) found at low-levels in certain intermediates and active pharmaceutical ingredients (APIs), even in the presence of boron from other sources.

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