Agilent Technologies, Inc.

Photodegradation of plastic products is known to accelerate weathering and the resulting release of chemical additives and particles to the environment, however these processes are complex. Here, eight different plastic consumer products were leached in double-distilled water under exposure to strong ultraviolet (UV) light for ten days, and the chemical composition of the leachates was compared to their respective dark controls. The leachates and plastic particles were investigated with a wide battery of chemical-analytical tools to broadly characterize the underlying processes and possible hazards. These covered (a) metal(loid) analysis, (b) microplastic analysis, (c) analysis of >70 organic target analytes and (d) nontargeted screening of the extracts.

Microplastics are defined as small plastic particles between 1 µm and 5 mm in size. Due to poor waste management and plastic pollution, they are now documented to be ubiquitous in the environment.1,2 However, pathways of dietary exposure to microplastics are not yet fully understood. The consumption of bottled water has been calculated to increase by 7% annually, with an estimated mean total global consumption of bottled water to be 513 billion liters by 2025. This study demonstrates how the Agilent 8700 Laser Direct Infrared (LDIR) Chemical Imaging System can accurately identify and quantify the presence of microplastics in bottled drinking water. This study also shows the capability of the Agilent Cary 630 FTIR spectrometer to investigate the source of microplastic contamination.

Reports of the omnipresence of microplastics have mainly focused on their presence in the environment, but there is a growing interest in investigating the health impacts of microplastics. Many people would assume that infants' exposure to microplastics would be limited. However, infant formula was found to be a possible exposure pathway. Extracting and isolating microplastics from infant formula can be difficult due to the range of formulations, ingredients, and components, such as fats, proteins, minerals, vitamins, and sugars. This application note demonstrates the importance of quality control in microplastics analysis. The study also shows how the Agilent 8700 Laser Direct Infrared (LDIR) Chemical Imaging System can accurately identify and quantify microplastics in infant formula.

This comprehensive peer-reviewed set of more than 600 definitions covers topics of interest for the biopharmaceutical and gene therapy subjects of genetics, therapeutics, drug development, clinical medicine, and the analytical science tools used for characterization of drugs. This glossary serves as a helpful reference to both novice and advanced scientists, engineers, and business executives involved with biopharmaceuticals and gene therapy technologies. Online sources of information for topics covered in this guide are also included for additional insights.

Agilent workflow solutions, designed for the food and beverages industry, serve as a comprehensive resource for testing alternative proteins. This compendium provides 15 applications across various domains, such as taste and flavor, nutrition, food quality, and food safety leveraging advanced analytical techniques like ICP-MS, LC/MS, GC/MS, and HPLC.

Learn how PFAS, microplastics, and chromium detection in environmental samples can be greatly enhanced with the latest LC-MS, laser directed IR spectroscopy, and IC-ICP-MS technologies

This application note describes the evaluated quantification performance of eight nitrosamine impurities using an Agilent 6495D triple quadrupole LC/MS (6495D LC/TQ) system coupled with an Agilent 1290 Infinity II bio LC system and Agilent APCI source.

Recently, attention has been drawn to the use of microdroplet reactions for antibody analysis. The NIST IgG1 mAb was used to optimize microdroplet reaction conditions on two reactions, IdeS cleavage and disulfide bond reduction, using the Agilent Jet Stream ESI source.

In this app note you will learn how to develop a highly specific, sensitive, and reproducible method for the quantitation of N-nitroso dabigatran etexilate impurity in dabigatran etexilate mesylate drug substance using an Agilent 6495C triple quadrupole LC/MS (LC/TQ) coupled to an Agilent 1290 Infinity II LC.

This application note presents an alternative method using time-of-flight liquid chromatography/mass spectrometry (TOF LC/MS) and hydrophilic interaction chromatography (HILIC) that enables accurate and repeatable analysis of diverse oligonucleotides without using ion-pairing reagents.

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The study of Per- and Polyfluoroalkyl Substances (PFAS) is vital for understanding the impact of these persistent chemicals on our health and environment, as well as developing effective mitigation strategies:

Webinar Date/Time: Thu, Nov 9, 2023 2:00 PM EST

GPC/SEC-viscometry enables measurement of true molar masses for carrageenan and detects subtle differences between samples with similar molar mass distributions.

GPC/SEC-MALLS analysis of hyaluronic acid obtains absolute molar mass while conventional GPC/SEC with concentration detectors only provides apparent molar masses.

This technical overview discusses best handling practices for IVT mRNA and analysis with the Fragment Analyzer systems, including sample handling and quantification tips.

Discover how SEC can be used in biopolymer applications including bioconjugates, proteins, mAbs, mRNA1, viruses, extracellular vesicles, and liposomal nanoparticles.

This paper discusses sustainable solutions for size separation of macromolecules that align with the 12 principles of green chemistry.

Tips & Tricks designed to support GPC/SEC users in their daily work, providing comprehensive overviews on different aspects of this powerful technique.

Robust, reliable GPC/SEC analysis of saccharides and polysaccharides can occur with very high resolution using Agilent SUPREMA columns with 3 and 5 µm particles.