Attaining Parts Per Quadrillion (PPQ)-Level Quantitation of PFAS in Untreated Water and Drinking Water

Join this webinar to learn about a novel Feed Injection technique that employs the new Agilent Hybrid Sampler in combination with a high-end LC triple quadrupole mass spectrometer equipped with iFunnel technology. This technique allows for the direct analysis of 80–100% organic solvent PFAS extracts in drinking water at or below 1 ng/L without experiencing any detrimental solvent effects.

Register Free: https://www.chromatographyonline.com/lcgc_w/ppq

Event Overview:

The analysis of per- and polyfluorinated alkyl substances (PFAS) at increasingly lower levels dictates the need for sample extraction and pre-concentration techniques such as solid-phase extraction (SPE) into an organic solvent to meet the required detection limits. Injecting high sample volumes could, in principle, improve sensitivity and therefore allow lower detection limits to be achieved. However, reversed-phase liquid chromatography (LC) does not lend itself to large-volume injection of extracts with high organic content due to the high elution strength of the sample solvent causing peak broadening, tailing, and splitting.

This webinar will demonstrate the use of a novel Feed Injection technique using the new Agilent Hybrid Sampler in combination with a high-end LC triple quadrupole mass spectrometer equipped with iFunnel technology. This allows for the direct analysis of 80–100% organic solvent PFAS extracts in drinking water at or below 1 ng/L without experiencing any detrimental solvent effects. The combination of the Hybrid Sampler with a novel design C18 reversed-phase column enables excellent chromatographic fidelity in high organic content mobile phases, meeting current EU2184, EPA 537.1, EPA 533 and EPA 8327 regulations.

The presentation will also show viewers how to increase the sensitivity further, using the Feed Injection approach in combination with the large volume injection of PFAS SPE extracts in drinking water to allow ppq-level quantitation at or below 1 pg/L.


Key Learning Objectives

1. Understand practical considerations for analytical set-up and prevention of sample contamination.
2. Learn how the Feed Injection technique allows PFAS samples in a high organic solvent to be analyzed.
3. Learn how iFunnel LC-Triple quadrupole mass spectrometry meets the sensitivity requirements for trace PFAS analysis.
   

Who Should Attend

• Water and wastewater analytical scientists
• Water testing laboratory managers
• Academic environmental researchers

Speakers:

Day Powell
Environmental Application Specialist
Agilent

Day Powell currently works at Agilent as an environmental application specialist. Prior to this, he worked for United Utilities, a major United Kingdom water supplier, as a technical specialist responsible for developing new methodologies for both LC-MS and GC-MS applications. Day has developed quantitative PFAS methods for several years and has helped United Utilities achieve UKAS accreditation for a novel method for determining 47 PFAS in drinking water using direct injection to address the latest Drinking Water Inspectorate regulations.

Matthias Kamuf, PhD
R&D Applications Chemist
Agilent

Matthias Kamuf, PhD, joined Agilent in 2016 as an R&D scientist. Since then, he has worked on various development projects, mainly for developing consumables for LC instruments. Lately, he has focused on developing products specifically designed for high-sensitivity PFAS applications requiring the lowering of chemical background to maximize analytical sensitivity.

Register Free: https://www.chromatographyonline.com/lcgc_w/ppq