Two-dimensional liquid chromatography (2D-LC) coupled to mass spectrometry (MS) has been used to separate proteins in the venom of the Indian cobra snake.

Ping Wei powder is a type of traditional Chinese medicine used to treat digestive system diseases. Its growth in popularity has led to scientists seeking to properly identify its chemical profile.

Ceftazidime and avibactam are two anti-infective drugs that can prove difficult to analyze in serum. Determining them can assist in therapeutic drug monitoring or pharmacokinetic studies.

Researchers leveraged the advantages of thermodesorption, followed by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC/TOF-MS), to compare and assess a variety of sampling phases for body odor.

LCGC International spoke to Adrián de la Fuente and Silvia Valverde Bastardo from the University of Valladolid, Spain, about the development of a miniaturized headspace solid-phase microextraction gas chromatography–quadrupole time-of-flight mass spectrometry (HS-SPME-GC–QTOF-MS) method for the analysis of biogenic volatile organic compounds (BVOCs) emitted by native Spanish trees.

As part of the collaboration, BASF will contribute its R&D expertise in catalytic materials and technologies, while Mingyang will focus on applying its research capabilities to Power-to-X equipment.

Novichok nerve agents are lethal substances when improperly handled. The researchers from the University of Helsinki aimed to find new ways of neutralizing Novichok A-234.

Duodenal mucosal resurfacing (DMR), a new-style endoscopic procedure using hydrothermal energy to ablate this thickened layer, shows promise for enhancing glucose and lipid metabolism in type 2 diabetes patients. However, the mechanisms driving these improvements remain largely unexplored. Researchers investigated the mechanisms by which DMR improves metabolic disorders using a rat model. Gut microbiota and metabolomics profiles were analyzed through 16S rRNA gene sequencing and ultrahigh pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).

Flavonoids are widely used metabolites that carry out various functions in different industries, such as food and cosmetics. Detecting, separating, and quantifying them in fruit species can be a complicated process.

Highly reactive aldehydes can pose significant health concerns in polluted environments. HPLC was used in this study to simultaneously analyze carbonyl compounds hydrazones.

A recent study conducted at the University of Georgia, (Athens, Georgia) presented a validated method for quantifying 18 terpenes in Cannabis sativa essential oil, extracted via hydrodistillation. The method, utilizing gas chromatography–mass spectrometry (GC–MS) with selected ion monitoring (SIM), includes using internal standards (n-tridecane and octadecane) for accurate analysis, with key validation parameters—such as specificity, accuracy, precision, and detection limits—thoroughly assessed. LCGC International spoke to Noelle Joy of the University of Georgia, corresponding author of this paper discussing the method, about its creation and benefits it offers the analytical community.

Shimadzu researchers aimed to develop a more efficient supercritical fluid chromatography method for solid-state injection and streamlining sample pretreatment.

Here is some of the most popular content posted on LCGC International this week.

Green analytical chemistry is no longer a niche concept but a necessity in today’s environmentally conscious world.

We spoke with Josh Hoerner, general manager of Purisys, which specializes in a small volume custom synthesis and specialized controlled substance manufacturing, to gain his perspective on FDA’s recommendations for acceptable intake limits for N-nitrosamine impurities.