Jonathan Zweigle of the University Tübingen spoke with LCGC International about his work using non-targeted screening based on high-resolution mass spectrometry (HRMS) to detect PFAS in soil samples. HRMS allows scientists to determine the elemental and isotopic composition of a sample with high accuracy.

Researchers from Bristol Myers Squibb and Sanofi recently tested a new means of using hydrophobic interaction chromatography (HIC) for removing impurities in monoclonal antibodies (mAbs).

An illuminating session at the International Symposium on Chromatography focused on currents trends and misconceptions surrounding oligonucleotide analysis.

Northwest University and Shaanxi Institute for Food and Drug Control scientists recently tested a new means of separating bioactive compounds from herbal extracts.

Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.

In this article, the use of comprehensive two-dimensional liquid chromatography (LC×LC) coupled to mass spectrometry (MS) for characterizing glycosylation of therapeutic enzymes is presented.

It has been more than five years since the last update in this column on the evolution of the Hydrophobic Subtraction Model (HSM) of reversed-phase selectivity and characteristics of new stationary phases recently characterized using the model. In this installment, Dwight Stoll discusses the continuing evolution of the model.

The 2024 International Symposium on Chromatography (ISC) provided attendees not only had the opportunity to learn about the latest breakthroughs in chromatography but also to engage in meaningful discussions about the future of the field.

ISC 2024 in Liverpool, U.K. included an illuminating session on contemporary omics applications.

This paper describes the content of a well-written analytical procedure for regulated high-performance liquid chromatography (HPLC) testing. A stability-indicating HPLC assay for a drug product illustrates the required components for regulatory compliance, including additional parameters to expedite a laboratory analyst’s execution.

Hydrophilic interaction chromatography–mass spectrometry (HILIC-MS) offers a flexible and efficient alternative to ion-pairing reversed-phase liquid chromatography (IP-RPLC) for oligonucleotide analysis, with column selectivity and mobile phase pH being key factors in optimizing retention and detection.

A recent study aimed to characterize the fine-flavor cocoa in parent-hybrid combinations using widely targeted gas chromatography-mass spectrometry (GC–MS) and bean phenotype analysis.

A recent joint study between the Department of Forensic Science of the College of Criminal Justice at Sam Houston State University (Huntsville, Texas) and the Department of Criminal Justice of the School of Social Sciences at Ming Chuan University, (Taipei, Taiwan) developed artificial intelligence (AI) by transfer learning in a convolutional neural network (CNN), GoogLeNet, with the image classification AI fine-tuned to create intelligent classification systems to discriminate samples containing gasoline residues from burned substrates.

In this LCGC Blog, Daipayan Roy and Muhammed Qamar Farooq of Amgen discuss the history and impact of supercritical fluid chromatography (SFC) throughout the years.

Separation and Characterization of Macromolecules 11 (SCM-11) will take place from 22–24 January 2025 in Amsterdam, The Netherlands.