Waters to distribute LC method development software
Waters is to become the exclusive distributor of Fusion Method Development software developed by S-Matrix.
Waters is to become the exclusive distributor of Fusion Method Development software developed by S-Matrix. The software works with the company’s chromatography data software and UPLC systems to automate liquid chromatographic method development according to Quality-by-Design (QbD) guidelines.
According to the company, using a QbD-based methodology for LC method development allows scientists to develop the best possible method faster and with greater confidence. The software is reported to increase lab efficiency by designing statistically valid experiments and automatically reconstructing them in the chromatography data software as fully ready-to-run sequences. The resulting data is used to generate parameter-effects models that establish the final design and operating spaces for truly optimized LC methods. This automated process ensures that scientists develop the right method the first time and translate chromatographic data into information, knowledge and answers.
An article published in LCGC North America, demonstrated that through the use of this software with a UPLC system, method development time for a complex drug product could be reduced from 45–60 days to two days when compared with the conventional one-factor-at-a-time development approach. To view that article on-line click here
For more on the companies visit www.waters.com and www.smatrix.com
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
