Sunday One-Day Short Courses

Three one-day short courses will be held on Sunday, June 3, from 9:00 am–4:30 or 5:00 pm. Course registration and badge pick-up is at 8:00 am on Sunday, and lunch and refreshment breaks will be provided.

Perry G. Wang will host Course 17, “Introduction to GLP Regulations and Bioanalytical Method Validation by LC–MS/MS.” Wang is a chemist in the Office of Regulatory Science, US Food and Drug Administration (FDA). The course will focus on GLP regulations and the bioanalytical method validation for drugs and metabolites in biological matrices using LC–MS/MS. The course is designed to help students comply with FDA’s regulations for drug discovery and development in the pharmaceutical industry and contract research organizations. It will reflect the contents of the updated guidance and recently published white papers with regard to bioanalytical method validation using LC–MS/MS. International harmonization of bioanalytical method validation guidance will also be discussed.

Wang received his B.S. degree in Chemistry from Shandong University in Jinan, China. He earned his M.S. and PhD degrees in Environmental Engineering from Oregon State University, in Corvallis, Oregon.

Course 18, “Ion Mobility Mass Spectrometry: An Introduction to Instrumentation, Applications, and Data Analysis,” is the topic of a course taught by Brian H. Clowers of Washington State University in Pullman, Washington, Erin Baker of Pacific Northwest National Laboratory (PNNL) in Richland, Washington, and John A. McLean of Vanderbilt University in Nashville Tennessee. The course provides students with a basic understanding of the most common instrumental configurations, experimental sequence, best practices, and the theory underlying the different types of ion mobility systems employed both in academic and commercial settings. An overview of hyphenated IMS-MS instrumentation with multiple practical applications and experimental designs will be presented including comparative discussions on advantages and disadvantages between different stand-alone and hyphenated techniques. The course offers a comprehensive look at ion mobility spectrometry and its use in modern analytical chemistry.

Clowers is an associate professor in the Department of Chemistry at Washington State University, where he received his PhD. Baker is a bioanalytical chemist at PNNL. She received her PhD in Chemistry from the University of California, Santa Barbara. McLean is a professor of Chemistry at Vanderbilt University. He received his PhD from George Washington University in Washington D.C.

Course 19, “Advanced Metabolomics: Bioinformatics, Activity, and Pathways” will be taught by Gary Siuzdak, H. Paul Benton, and Xavi Domingo, of the Scripps Research Institute in La Jolla, California, and Erica Forsberg, of San Diego State University in San Diego, California. The course will complement the other ASMS Metabolomics short course, going into greater depth on key informatic topics that are critical to scientists trying to establish themselves in the field. Topics include metabolomics activity screening, assessing statistically relevance, pathway analysis, and systems biology guided by metabolomics.

Siuzdak is a professor and director at the Center for Metabolomics at the Scripps Research Institute. He received his PhD in Physical Chemistry from Dartmouth College in Hanover, New Hampshire. Benton received his PhD from Imperial College in London, England. He is currently a visiting scientist in the Siuzdak laboratory. Domingo received his PhD in Bioengineering from the Universitat de Lleida in Lleida, Spain. He is a research line manager at Eurecat – Technology Centre of Catalonia. Forsberg is an assistant professor in analytical and bioanalytical sciences at San Diego State University. She received her PhD in Chemical Biology from McMaster University in Hamilton, Ontario, Canada.