Simultaneous Determination of Nicotine and Metabolites by LC-MS Using an Acclaim Mixed-Mode HILIC-1 Column

Sensory Directed Analysis quickly identifies off-odors associated with lipid oxidation in food products such as edible oils and fats. Automated solventless extraction of food products is carried out using DHS or direct thermal extraction. This is followed by a concentration step and GC-O/MS determination of odors. The use of olfactory and MS detection enables the simultaneous determination of sensory-active regions of the chromatogram and mass spectral identification of associated compounds. The dedicated evaluation software ensures an efficient identification of the off-odors based on the GC-O/MS data.

Fully automated method for 3-MCPD and Glycidol determination in edible oil by GC-MS, based on the widely used methods ISO 18363-1, AOCS Cd 29c-13, and DGF C-VI 18 (10). The automated GC-MS determination of 3-MCPD and glycidol in edible oils with evaporation step and GC column backflush ensures low LODs by eliminating excess derivatization reagent for improved method stability and system ruggedness.

Fully automated method for 3-MCPD, 2-MCPD and Glycidol determination in Edible Oil and Fat based on ISO 18363-4 - Zwagerman/Overman with validation data. A recent upgrade to PTV injection has further improved the quality and robustness of results. Fatty acid esters of 3- and 2-monochloropropanediol (3-MCPD-e, 2-MCPD-e) and glycidol (Gly-e) are process contaminants that are formed, for example, when edible oils and fats are refined. After ester cleavage during digestion in the human body they pose a relevant health risk and therefore need to be determined in edible oils and fats and in fat containing food.

The AppNote describes the fully automated determination of MOSH/MOAH in Food and Packaging extracts following DIN EN 16995. Industrial production, processing and transportation invariably put food at risk of contamination with MOSH/MOAH. To ensure a reasonable cost benefit balance, high laboratory productivity and good quality of results, leading contract laboratories increasingly strive to automate their processes. An example is the determination of MOSH/MOAH using a LC-GC-FID Coupling Platform. Depending on the sample matrix, additional automated sample preparation by aluminum oxide clean-up, epoxidation, and/or saponification is necessary prior to analysis. The dedicated evaluation software integrates the complex MOSH/MOAH chromatograms accurately and reproducibly.

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Scientists recently studied how different factors affect antisense oligonucleotides (ASOs) under hydrophilic interaction liquid chromatography (HILIC) conditions.