Separation Sciences
The first presentation in this Tuesday morning session will be given by Tadeusz Gorecki of the University of Waterloo and is titled “Comprehensive Multidimensional Separations: Can They Get Better?” Gorecki will discuss both GCxGC and LCxLC separations and will present examples of both approaches.
Session 870
Room 308B
10:05-11:25 a.m.
The first presentation in this Tuesday morning session will be given by Tadeusz Gorecki of the University of Waterloo and is titled “Comprehensive Multidimensional Separations: Can They Get Better?” Gorecki will discuss both GCxGC and LCxLC separations and will present examples of both approaches.
Next, Yuki Hiruta of Keio University will present a talk titled “Antibody Purification Using Temperature-Responsive Hydrogel Modified Silica Beads.” This presentation will describe a purification method for proteins such as monoclonal antibodies that involves the use of a solid-phase extraction system that enables control of elution behavior by adjusting the temperature of an aqueous eluent with neutral pH.
The next presentation, to be given by Muhammad Zahid of the University of Agriculture Faisalabad, Pakistan, is titled “Enhanced Extraction of Bioactive Components from Aloe barbadensis Miller Using Environmental Friendly Deep Eutectic Solvents.” Deep eutectic solvents are emerging green solvents that can be used for highly efficient extraction of natural products from plant biomass. They can also be used as safe extraction media for bioactive compounds used in applications such as cosmetics, food flavors, and pharmaceuticals.
The session’s final presentation, titled “From a Pit to a Ladder: Strategies and Techniques for Improved Biomacromolecule Separations,” will be given by Cory E. Muraco of MilliporeSigma. This presentation will discuss selected aspects of size-exclusion, hydrophobic interaction, ion-exchange, hydrophilic interaction, and reversed-phase chromatography, as well as the development of robust and reproducible analytical chromatographic schemes for separating protein and antibody mixtures.
New Study Uses MSPE with GC–MS to Analyze PFCAs in Water
January 20th 2025Scientists from the China University of Sciences combined magnetic solid-phase extraction (MSPE) with gas chromatography–mass spectrometry (GC–MS) to analyze perfluoro carboxylic acids (PFCAs) in different water environments.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ion used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
A Guide To Finding the Ideal Syringe and Needle
January 20th 2025Hamilton has produced a series of reference guides to assist science professionals in finding the best-suited products and configurations for their applications. The Syringe and Needle Reference Guide provides detailed information on Hamilton Company’s full portfolio of syringes and needles. Everything from cleaning and preventative maintenance to individual part numbers are available for review. It also includes selection charts to help you choose between syringe terminations like cemented needles and luer tips.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Oasis or Sand Dune? Isolation of Psychedelic Compounds
January 20th 2025Magic mushrooms, once taboo, have recently experienced a renaissance. This new awakening is partially due to new findings that indicate the effects of psilocybin, and its dephosphorylated cousin psilocin may produce long lasting results for patients who might be struggling with anxiety, depression, alcohol and drug abuse, and post-traumatic stress disorder. Hamilton Company has developed a methodology for the isolation and identification of 5 common psychedelic compounds used in the potential treatment of disease. The PRP-1 HPLC column resin remains stable in the harsh alkaline conditions ideal for better separations.
