Scientists from Taiwan Develop Compatible Method for DLLME with Reversed-Phase HPLC
Scientists from Taiwan have developed a method for dispersive liquid-liquid microextraction of ionisable compounds that renders it compatible with reversed-phase HPLC by combining it with in-syringe back extraction. The new system was demonstrated with the removal of the drug clenbuterol from water.
Scientists from Taiwan have developed a method for dispersive liquid-liquid microextraction (DLLME) of ionisable compounds that renders it compatible with reversed-phase HPLC by combining it with in-syringe back extraction. Ming-Ren Fuh and Mahaveer Melwanki from Soochow University in Taipei introduced in-syringe extraction as the final step to produce an analyte solution suitable for HPLC. They illustrated the technique with the extraction of clenbuterol from water. Fuh and Melwanki regard the speed of this combined extraction process to be the major advantage, the longest step being centrifuging the sample to collect the droplets of dispersed solvent.
LCGC’s Year in Review: Highlights in Liquid Chromatography
December 20th 2024This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.
Next Generation Peak Fitting for Separations
December 11th 2024Separation scientists frequently encounter critical pairs that are difficult to separate in a complex mixture. To save time and expensive solvents, an effective alternative to conventional screening protocols or mathematical peak width reduction is called iterative curve fitting.
Mobile Phase Buffers in Liquid Chromatography: A Review of Essential Ideas
December 11th 2024In this installment of "LC Troubleshooting," Dwight Stoll discusses several essential principles related to when and why buffers are important, as well as practical factors, such as commonly used buffering agents, that are recommended for use with different types of detectors.
