Reseachers Detect Bladder Cancer in Human Urine with HPLC/MS
Researchers conducting clinical research trials of patients with bladder cancer have discovered a non-invasive way to detect the cancer by using HPLC/MS.
Researchers conducting clinical research trials of patients with bladder cancer have discovered a non-invasive way to detect the cancer by using HPLC/MS. In the current study using sophisticated statistical methods the researchers were able to identify and characterize urine metabolite profiles obtained from patients with bladder cancer over controls. Identification and quantitative measurements of all the metabolites expressed in urine, serum, plasma, and tissue are essential for the study of biological processes in normal and disease states. High performance liquid chromatography was used to resolve the metabolites in urine that were detected by mass spectrometry according to their mass-to-charge ratio. Mass spectrometry was selected for this study because of its sensitivity.
The next step in their research will be the identification of key metabolites that are typical to patients with superficial bladder cancer. This may help to improve and simplify diagnosis of patients with bladder tumors. Furtherer more it will help to better understand their role in the pathophysiology of the disease and possible as a future target for therapeutic intervention.
LCGC’s Year in Review: Highlights in Liquid Chromatography
December 20th 2024This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.
Next Generation Peak Fitting for Separations
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The Chromatographic Society 2025 Martin and Jubilee Award Winners
December 6th 2024The Chromatographic Society (ChromSoc) has announced the winners of the Martin Medal and the Silver Jubilee Medal for 2025. Professor Bogusław Buszewski of Nicolaus Copernicus University in Torun, Poland, has been awarded the prestigious Martin Medal, and the 2025 Silver Jubilee Medal has been awarded to Elia Psillakis of the Technical University of Crete in Greece.
