Monoliths as Stationary Phases for Separating Biopolymers – Fourth-Generation Chromatography Sorbents

Publication
Article
LCGC North AmericaNovember 1999
Volume 17
Issue 11
Pages: 998–1005

Monoliths are chromatography sorbents cast as a homogenous phase into chromatography columns as a single, continuous piece. In contrast, regular chromatographic solvents are packed as individual particles. In this month's "Column Watch," the guest columnists compare three of these novel sorbents with a conventional packed-particle column in terms of porosity, static, and dynamic capacity. Monoliths show flow rate–independent separation efficiency and dynamic capacity as well as higher porosity than conventional columns.

LCGC 17(11), 998–1005 (1999).
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