Is HILIC Permanently Changing the Scene for HPLC Separations?
The separation of mixtures of polar and hydrophilic compounds can be a significant challenge.
The separation of mixtures of polar and hydrophilic compounds can be a significant challenge. Hydrophilic interaction liquid chromatography (HILIC) has proven to be a solid alternative for such applications. Its use has therefore increased rapidly during the last years and HILIC has become a cornerstone in many laboratories.
Assessing Thorium-Peptide Interactions Using Hydrophilic Interaction Liquid Chromatography
February 4th 2025Paris-Saclay University scientists used hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS) and inductively coupled plasma mass spectrometry (ICP-MS) to assess thorium’s interaction with peptides.
HILIC Peptide Retention Times Predicted Using New Approach
October 29th 2024Manitoba Centre for Proteomics and Systems Biology scientists produced a new means of predicting peptide retention times for hydrophilic interaction liquid chromatography (HILIC) at acidic pH in formic-acid based eluents.
