Cooking at high temperatures causes a chemical reaction between certain sugars and asparagine which causes acrylamide formation. In this technical note, we explore how to use Novum™ SLE tubes to clean up a coffee matrix in order to quantitate known acrylamide levels. The recovery is especially significant when you consider the polar nature of the acrylamide (LogP -0.27). In addition to high recoveries (>90 %), the low values for the standard deviation and %CV indicates method reproducibility.
Polysorbate Quantification and Degradation Analysis via LC and Charged Aerosol Detection
April 9th 2025Scientists from ThermoFisher Scientific published a review article in the Journal of Chromatography A that provided an overview of HPLC analysis using charged aerosol detection can help with polysorbate quantification.
Removing Double-Stranded RNA Impurities Using Chromatography
April 8th 2025Researchers from Agency for Science, Technology and Research in Singapore recently published a review article exploring how chromatography can be used to remove double-stranded RNA impurities during mRNA therapeutics production.