Environmental Analysis with GC and GC-MS
There is always a lot of buzz about environmental issues, ways to test for toxins, and other safety measures at Pittcon. With that in mind, Monday morning's Session 410 titled, "Environmental Analysis with GC and GC-MS," was both informative and refreshing.
There is always a lot of buzz about environmental issues, ways to test for toxins, and other safety measures at Pittcon. With that in mind, Monday morning’s Session 410 titled, “Environmental Analysis with GC and GC-MS,” was both informative and refreshing.
The session began with University of Waterloo’s Suresh Seethapahty’s discussion titled, “Vial-Based Permeation Passive Samplers – Design, Calibration, Environmental Effects on Uptake Rates and Field Applications.” Following this talk was another informative presentation titled, “Comparing GC/Q with a New GC/QQQ for Pesticide Residue Analysis,” by Philip L. Wylie of Agilent Technologies.
“A Method for Screening of Household Dust for Environmental Contaminants with GCxGC-TOFMS,” was the next topic presented by Donald C. Hilton of LECO Corporation. Next up was “Multidimensional HPLC x HRGC-MS Coupling for Multi-Residue Pesticide Analysis in Food and Environmental Samples,” given by Nieves Sarrion of Konik-Tech.
After a brief recess the session continued with a presentation by Dalel Benali, of Veolia Environment, entitled, “Analytical Characterization of NEW Disinfection Byproducts in Drinking Water.” Following that discussion was another presentation focusing on pesticides, “Evaluating a Method to Analyze Pesticides at the Low ppb Level Using GC/MS with Large Volume Injection, Deconvolution Reporting Software, and a Retention Time Locked Pesticide Library,” given by Philip L. Wylie of Agilent Technologies.
Another interesting presentation from Veolia Environment was given by Christophe Tondelier titled, “On Tap Off-flavor Compounds Enrichment: A.R.I.S.T.O.T. Qualitative and Quantitative Analysis.” Finally, rounding out this session was a presentation by Faten Belhadjkaabi of Anjou Recherche titled, “Sludge Carbohydrates Monitoring by Gas Chromatography Coupled with Mass Spectrometry.” Overall, it was a very enjoyable session for any GC and GC-MS aficionado.
Inside the Laboratory: The Zydney Group at Pennsylvania State University
November 26th 2024In this edition of “Inside the Laboratory,” Andrew Zydney of Pennsylvania State University discusses his laboratory’s work with using high performance liquid chromatography (HPLC) to analyze biopharmaceutical products before and after membrane separation processes.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Merck: Obtaining Ultrapure Water for Sensitive PFAS Analysis by LC-MS
November 26th 2024Ultrapure water from a Milli-Q® water purification system was tested for PFAS according to the draft EPA 1633 method. None of the 40 PFAS compounds tested were detected in the ultrapure water produced by a Milli-Q® IQ 7000 system fitted with a LC-Pak® polisher at the point-of-dispense, making it suitable for the most sensitive PFAS analyses by LC- MS/MS.
Measuring Stress and Reproductive Hormones in Dolphins with UHPLC
November 25th 2024A recent study measured stress and reproductive hormones in three stocks of free-ranging bottlenose dolphins inhabiting different natural salinities across the Gulf of Mexico, with hormones extracted from the blubber of 82 remotely biopsied dolphins and quantified using ultrahigh-pressure liquid chromatography (UHPLC) coupled with orbital ion trap fusion mass spectrometry.
