Engineering Advances in High Temperature GPC Instrumentation
We discuss polyolefins and high temperature GPC in terms of engineering advances.
The first GPC instrument incorporated a pump, an injection valve, a column oven and a RI detector. Quite some engineering ingenuity was required in those days to have a constant flow pump that was particularly required in GPC, where a small change in flow could cause large molar mass errors, and to have a stable RI detector at high temperature (with RI being known to have strong temperature dependency). It is interesting to notice that the very first GPC was targeted at high temperature applications. This certainly showed the importance that the knowledge of the molar mass distribution of polyolefins had in the design of new resins. This leads us on to discuss polyolefins and high temperature GPC in terms of engineering advances.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
2024 EAS Awardees Showcase Innovative Research in Analytical Science
November 20th 2024Scientists from the Massachusetts Institute of Technology, the University of Washington, and other leading institutions took the stage at the Eastern Analytical Symposium to accept awards and share insights into their research.
