Eliminating matrix effects: LC–MS analysis of biological fluids

Here is some of the most popular content posted on LCGC International this week.

Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.

At the Recent Advances in Food Analysis (RAFA) conference in 2024, LCGC International sat down with Stefan van Leuwen of Wageningen Food Safety Research to discuss his research, which addresses emerging challenges in circular food production, focusing on the risks posed by pollutants when waste and by-products are repurposed in food systems.

Harbin University of Commerce and Northeast Forestry University scientists led efforts to create new means of analyzing components in traditional Chinese medicine.

Discover how Chong Kun Dang (CKD), a leading South Korea Pharmaceutical Company, has transformed the operation of chromatography systems in their Quality Control (QC) Lab with the implementation of waters_connect System Monitoring.