Detection of Pesticides in Drinking Water with Xevo TQ-S
Waters Xevo TQ-S is designed for the most demanding quantitative UPLC/MS/MS applications. Using direct injection on Xevo TQ-S removes sample preparation and enables a simple, high-throughput analysis of pesticides in drinking water.
Xevo™ TQ-S from Waters® is designed for the most demanding quantitative UPLC®/MS/MS applications. It features a revolutionary new off-axis ion source technology, known as StepWave™, which increases even further the high sensitivity provided by Xevo TQ. This advance in performance allows you to accurately, robustly, and reproducibly measure compounds at much lower concentrations than you ever thought possible. Xevo TQ-S also features ScanWave™ collision cell technology to provide enhanced spectral LC/MS/MS data acquisition capabilities. Unlike conventional tandem quadrupole mass spectrometers, the Xevo TQ-S is designed to provide not only the very best quantitative data, but also superior spectral MS/MS information. Using direct injection on Xevo TQ-S removes sample preparation and enables a simple, high-throughput analysis of pesticides in drinking water. This is possible with ultra-sensitive detection down to ppq or pg/L concentrations to enable real background concentrations in samples to be observed. The RADAR mode of acquisition enables the collection of spectral information on background components in the sample matrix while simultaneously collecting MRM data. This can help identify areas of potential ion suppression, observe untargeted contaminants, and aid in the development of matrix reduction strategies.
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The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Investigating Phenolic Content in Walnut Milk Residue with UPLC-ESI-MS/MS
January 13th 2025New research characterizes walnut milk residue according to its phenolic content and antioxidant and cytotoxic potential using ultra-performance liquid chromatography–electrospray tandem mass spectrometry (UPLC-ESI-MS/MS).
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
