Continuous, cryogen-free on-line monitoring of PAMS in ambient air using hydrogen carrier gas

This application note presents an advanced analytical system for the sensitive detection of trace-level air toxics in humid ambient air samples, in accordance with US EPA Method TO-15A. The cryogen-free preconcentration and thermal desorption approach, coupled to GC-MS, delivers exceptional chromatographic performance even for highly volatile and polar compounds. The system meets the stringent detection limit requirements of the latest air monitoring regulations, with method detection limits as low as 0.7 pptv. This innovative analytical solution provides a robust, cost-effective platform for the reliable quantification of hazardous air pollutants, enabling compliance with regulatory standards.

This application note outlines an analytical approach that meets the stringent requirements of EPA Method 327 for monitoring ethylene oxide and other hazardous air pollutants. The key innovation is the ability to achieve the required sensitivity without the need for liquid cryogen cooling, enabling more cost-effective and productive monitoring. Highlights include a 10 ppt method detection limit for ethylene oxide, effective management of sampling bias and chromatographic interferences, and straightforward method transfer between laboratories. The flexible, cryogen-free preconcentration system enables large-volume sampling to boost sensitivity while simplifying operation, making it an attractive solution for implementing the new EPA method.

Ultrapure water from a Milli-Q® water purification system was tested for PFAS according to the draft EPA 1633 method. None of the 40 PFAS compounds tested were detected in the ultrapure water produced by a Milli-Q® IQ 7000 system fitted with a LC-Pak® polisher at the point-of-dispense, making it suitable for the most sensitive PFAS analyses by LC- MS/MS.

Ultrapure water from a Milli-Q® water purification system was tested for PFAS according to the draft EPA 1633 method. None of the 40 PFAS compounds tested were detected in the ultrapure water produced by a Milli-Q® IQ 7000 system fitted with a LC-Pak® polisher at the point-of-dispense, making it suitable for the most sensitive PFAS analyses by LC- MS/MS.

This note demonstrates efficient PFAS extraction from contaminated surface water using automated mixed-mode µSPEed® cartridges and Tecan's Resolvex® Prep.

Crucial phosphorylated compounds can be analyzed by a polymeric iHILIC-(P) Classic HILIC column and MS. The method is applicable for targeted and non-targeted metabolomics.