Component Source Determination for Drugs, Pharmaceuticals, and Homeland Security Applications

The six presentations in this Tuesday morning session will examine various mass spectrometry techniques for determining analytes in a wide range of samples, including oysters, craft beers, Scottish malt whisky, a traditional Chinese medicine, a chemotherapy drug, and chemical warfare agents.

The first presentation in the session will be delivered by Marc E. Engel of the Florida Department of Agriculture and Consumer Services (Tallahassee, Florida) and is titled “The American Oyster, Crassostrea virginica: A Tale of Two Southern USA Coasts; The Analysis of Heavy Metal Contaminants by ICPMS.” Engel will discuss a comparison of the ICP-MS analysis of cadmium, lead, and mercury in oysters from the Gulf of Mexico and from the Indian River Lagoon.

Engel’s presentation will be followed by a talk to be given by Christine A. Hughey of James Madison University (Harrisonburg, Virginia) titled “Beer-omics: Molecular Fingerprinting of Craft Beers by High Resolution Mass Spectrometry.” Hughey will discuss how fingerprinting and targeted quantitation were used for differential analysis of 19 single-hop India pale ales.

Pat Langridge-Smith’s (SIRCAMS, University of Edinburgh, Edinburgh, UK) presentation, titled “Electrospray Ionization FT-ICR Mass Spectrometry Fingerprinting of Scottish Malt Whisky,” will focus on source classification of malt whisky using automatically assigned Fourier transform ion cyclotron resonance mass spectra.

Bai-Ping Ma of the Beijing Institute of Radiation Medicine (Beijing, China) will present a talk titled “Chemical Fingerprint for Panax notoginseng Powders by UPLC-Q-TOF-MSE.” Ma will discuss an LC–MS fingerprinting method for characterizing the chemical profile and conducting quality control of the traditional Chinese medicine P. notoginseng, also known as Sanqi or Tianqi.

The next presentation will be given by Arvind Thyagarajan of the IICMS (Chennai, India) and will be titled “Characterization of Trace Level Impurities of Small Molecules Through Simultaneous Multiple Collision MS-MS Spectroscopy.” In this presentation, Thyagarajan will talk about the unambiguous structural characterization of trace-level impurities in gemcitabine, a chemotherapy drug.

The final presentation in the session will be delivered by Kevin J. Shefcheck, of the U.S. Army-ECBC (Aberdeen Proving Ground, Maryland). His presentation, titled “Mass Spectrometric Based Analysis for Chemical Warfare Agent Metabolites in Biomedical Samples” will cover the GC–MS, GC–MS-MS, and LC–MS-MS detection of chemical warfare agents in urine.