E-Separation Solutions
Without question, the current acetonitrile shortage has become the hottest topic in the chromatography world in recent memory.
Without question, the current acetonitrile shortage has become the hottest topic in the chromatography world in recent memory. The influx of shortage-related articles, conservation tips, and even explorations of alternative separations instrumentation has been enormous at LCGC, with many brilliant and innovative ideas being presented to get laboratories through these hard times.
However, it is interesting that to date, so little attention has been paid to the underlying causes of this shortage, particularly in light of the large amounts of revenue that are tied to this seemingly innocuous solvent. Certainly, the reasons have been detailed, and the prevailing wisdom is that there are three: Hurricane Ike, the shutdown of one of the world’s largest acetonitrile producers in China, and, perhaps most tellingly, the decrease in production of acrylonitrile by car manufacturers, as acetonitrile is a byproduct of acrylonitrile production.
It is that third cause that is especially troubling, as it cuts to the heart of the current global economic crisis and at the same time, draws a direct link to the chromatography community. It is generally agreed that the subprime mortgage crisis was what started the global economic snowball rolling downhill, and this directly led to the depression of countless other markets, including the automobile industry and its industrial byproducts — such as acetonitrile. But all too often, it as at this point that “general agreement” ends, and the cries of “Wall Street greed” and “predatory lending” begin, as critical thought often gives way to populist anger.
For if we really want to get to the heart of why car production ground to a halt in the past year and hence, why you are currently doing all you can to preserve acetonitrile every day in the lab, one more logical step must be taken, and the populist anger aimed one rung higher on the ladder. While it is true that there have been many greedy individuals and corporations who contributed to the current economic mess, blaming them alone is a little like blaming a toddler for coloring the walls with markers you opened, handed him, and then asked him to use.
With “Government Sponsored Entities,” or GSEs, such as Freddie Mac and Fannie Mae at the heart of the mortgage crisis, one has only to connect the dots back to the late-1990s when their fatally flawed lending policies were enacted. At that time, GSEs were actively encouraged (some might say pushed by threat of investigation) by the presidential administration and its congressional allies to make the risky loans that resulted in the current mess — all in the name of expanding the dream of homeownership to borrowers who otherwise could not qualify. Stunningly, many of those same congressional leaders and high-ranking administration figures are the ones now leading the chorus against corporate greed and doing the most finger-pointing, which takes more than a little chutzpah. If we were to list names here, they would probably fill a phone book, but it is fairly safe to start at the top and work your down through our current congressional leadership.
So while the chromatography community waits — like the rest of the world — for the economy to recover and thereby allow the acetonitrile to begin flowing again, perhaps it would be helpful to affix the bullseye to the correct group of villains. It may not bring about the recovery any faster, but it might just help determine who in Washington still has a job come November 2010.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.