A Deep Dive into the Characterization of a Complex cIEF Electropherogram from an ADC Using a Novel Integrated icIEF-UV/MS System
Charge heterogeneity is present in most biopharmaceutical protein products. During the manufacturing process, charge heterogeneity of the protein therapeutics can occur due to enzymatic cleavage and chemical post-translational modifications (PTM). For therapeutics like ADCs, not only the antibody contributes to the heterogeneity but also the linker and payload, which add even more complexity to the charge variant profiles. Characterizing the charge heterogeneity of ADCs is essential for critical quality attribute (CQA) assessment to ensure drug safety, efficacy, and potency.
Infographic: Be confidently audit ready, at any time and reduce failures in pharma QC testing
November 20th 2024Discover how you can simplify the audit preparation process with data integrity dashboards that provide transparency to key actions, and seamlessly track long-term trends and patterns, helping to prevent system suitability failures before they occur with waters_connect Data Intelligence software.
6PPD-Quinone Reference Materials
November 19th 2024Ensure environmental and consumer health with our standards for 6PPD-quinone testing. 6PPD-quinone has been detected in the environment and has shown toxicity to aquatic life. Chiron, by Zeptometrix® offers reference standards suitable for Draft EPA Method 1634.
Current and Future Advancements in PFAS Research
November 19th 2024This white paper explores the health risks, environmental impacts, and detection technologies associated with PFAS, along with the latest advancements in PFAS research. It also provides an overview of the regulatory landscape and emphasizes the crucial role of companies like ZeptoMetrix® in supplying PFAS reference materials, which are essential for ensuring the accuracy of testing. Lastly, the paper outlines key areas for future PFAS research.
Microplastics Reference Materials
November 19th 2024The World’s First Microplastics Reference Materials. Our scientists have focused on these emerging global threats, and are excited to share Chiron MicroPrefs®, the first commercial microplastic reference material. The MicroPref® portfolio is designed to detect the six most abundant plastics in the environment and is available in a novel, easy-to-use tablet formulation. Be among the first labs to join in the fight against microplastic pollution by exploring the NEW line of Chiron MicroPrefs® microplastic standards.
