LCGC Europe-07-01-2012

The new version of EU GMP Annex 11 has been effective for about a year. There are new technical requirements in the Annex – do your laboratory computerized systems comply with them all? In this column we look at the impact of these new regulatory requirements for Good Manufacturing Practice laboratories.

This month's instalment presents the latest tools and accessories for the gas chromatographer. Have you got what you need in your troubleshooting toolkit?

The article investigates the ELSD response variation with supercritical carbon dioxide-based mobile phases and compares the response with HPLC.

What do you do when the peak shape changes?

The use of interactive liquid chromatography using porous graphite as a stationary phase and gradients of long chain alcohols and chlorinated aromatics to separate olefin-based elastomers according to their chemical composition is discussed.

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