June 2023

This review examines different workflows that have been designed and used to facilitate and/or automate method development in liquid chromatography (LC).

Building up knowledge of how different factors affect resolving power from a theoretical point of view, as well as what changes are possible within practical constraints, is powerful when we are confronted with a separation that needs to be improved, or when an existing separation is not performing as expected.

Nonspecific adsorption leads to poor peak shapes and poor performance from HPLC systems, but coating-enabling technologies can serve as a potential solution. We explain how.

The latest developments and challenges of using liquid chromatography (LC) for copolymer analysis are discussed.