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Gas Chromatography (GC)
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HPLC
Ion Chromatography
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Quality by Design (QbD)
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Size-Exclusion Chromatography (SEC)
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Ziqing Lin

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Ziqing Lin is a Senior Principal Scientist in the Chemical Process Development department at Bristol Myers Squibb. His primary focus is on analytical method invention for synthetic drug substances and antibody-drug conjugates. He holds a Ph.D. in Biomedical Engineering from Purdue University.

Articles

Scientist moved the vial of sample out from the tray autosampler of the Liquid Chromatography Mass Spectrometer LC/MS after the analysis was complete. | Image Credit: © S. Singha - stock.adobe.com

In-Loop Analyte Degradation in Two-Dimensional Liquid Chromatography: Example and Solutions

Ziqing Lin;Qinggang Wang;Dwight R. Stoll
September 13th 2024

In this installment of “LC Troubleshooting,” we describe an artifact that can arise because of compound degradation during the transfer of fractions of the first dimension (1D) column effluent to the 2D separation.

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