Shimadzu Corporation

Webinar Date/Time: Wed, Nov 6, 2024 2:00 PM EST

Due to their ability to tackle targets that were considered undruggable, oligonucleotides represent a key cornerstone of the future of personalized medicine. This infographic presents the different types of therapeutic oligonucleotides and highlights some innovative solutions for their analysis.

Discover how the Brevis™ GC-2050 is Leading the Way in Compact Gas Chromatography

Webinar Date/Time: Wed, Aug 7, 2024 11:00 AM EDT

Cannabinoid separation can be difficult with the presence of coeluting isomers. This application shows how a combination of LabSolutions MD (Method Development) software and powerful i-PDeA technology can help determine the optimal method for cannabinoid separation and deconvolute remaining co-eluting peaks after optimization.

This application showcases how a compact, affordable single quad LCMS can be easily integrated into existing laboratories for measurement of PFAS in diverse samples where adherence to regulated methods (e.g., EPA 533, 537.1, and 1633) is not required, or samples where expected concentrations are larger than sub ppb levels.

This application news presents instrument operating conditions and instrument method performance statistics, including method linearity, accuracy, and precision, for priority pollutant pesticides and PCB congeners. The method validated in this application acted as guidance in developing ASTM D8543 Test Method for Determination of OCPs and PCBs in Aqueous Solution by a GC/MS/MS which is intended for proposal to EPA as an alternative test procedure (ATP) for EPA 608.3

Webinar Date/Time: Thu, Jan 25, 2024 2:00 PM EST

Today’s SFC systems are widely accepted for analytical and preparative separation of chiral and achiral compounds related to pharmaceutical development. Shimadzu enhances the user experience by delivering a highly effective integration of analytical and prep SFC supported by a unified software platform. Learn how these solutions can be used for rapid screening of multiple analytical conditions, simplified method development, and purification at laboratory scale.

Whether you're an experienced user of SFC technology or just getting into it, this FAQ guide offers a wealth of knowledge to enhance your efficiency, troubleshoot common issues, and make the most of this dynamic tool. Learn about a wide range of topics, including hardware insights, advantages of SFC, applications, and column screening and matrix effects.

SFC can provide solutions for challenging separations beyond traditional normal- and reverse-phase HPLC. But to get the best results, you need to select the right columns. This eBook examines column options for accurately and efficiently separating a variety of pharmaceutical compounds using SFC. Topics include SFC column fundamentals and considerations, selecting SFC columns, and columns for SFC chiral and achiral analysis.

The Nexera UC UHPLC/SFC switching system combines both UHPLC and SFC analysis modes in a single system, allowing you to easily switch between the two techniques in as few as ten minutes without reconnecting flow lines. So, you get the added resolution of UHPLC and the added selectivity of SFC to quickly develop separations without compromising chromatographic accuracy. Learn about five key benefits.

This poster demonstrates the utilization of a highly sensitive and accurate LC-MS/MS method for the quantitation of select endogenous steroids using dried blood spots (DBS) serum separator cards.

The work illustrates a single LCMS method for the analysis of AZBT and AMBBT in five sartan drug substances, with full separation of all sartans and azido impurities achieved in only 8.5 minutes.

LabSolutions DB/CS software offers powerful support for ensuring compliance with data integrity requirements for all types of analytical instruments, and can be optimized for a wide range of laboratory sizes and operating styles. Download this file to learn more.

In this poster, the 40 PFAS from EPA method 1633 were used to generate a library from a single mixture, and then were confirmed to function for targeted library screening and untargeted identification in groundwater.

This work demonstrates the benefits of adding a compact single quad LCMS into an existing workflow for API screening and analysis.

Demonstrated in this work is the use of bioinert UHPLC and LC-MS to analyze oligonucleotides accurately and reproducibly, allowing for faster development and quality control.

In this poster, a triple quad LC-MS was used to quantify per- and poly-fluoroalkylated substances (PFAS) to meet the requirements set by the EPA 1633 draft method, which describes the analysis of forty PFAS in wastewater, solids, biosolids, and tissue samples.

This article shows that the N-glycans of ACE2, a receptor of SARSCoV-2, and their sialic acid linkage types can be easily evaluated using MALDI-TOF analysis.

This app note introduces the use of the Nexera XS inert UHPLC, which utilizes a metal-free flow path for accurate and reproducible analysis of nucleotides.  

This technical report covers how a column packed with small particle material can be used to optimize an analytical method for monoclonal antibody aggregates. 

This app note introduces an analytical method for the separation of oligonucleotides of different length by ion-exchange chromatography using the Nexera XS Inert. 

This app note covers aggregate analysis using a Shimadzu Shim-pack™ BioDiol size-exclusion chromatography column with the Nexera XS inert UHPLC.  

This application introduces the automated analysis of fluorescent diastereomers of the proteinogenic D/L-amino acids using derivatizing reagents with chiral structures.

This podcast will examine peak deconvolution with photodiode array detectors and how a unique software function can separate peaks that are not resolved on-column, yielding better detection results and minimizing method development and analysis time. The podcast will explore the development of this tool with a leading pharmaceutical company and provide examples of how it can have an impact across a wide range of disciplines in the pharma/biopharma arena, from development to production.

This article introduces a comprehensive fractionation for both UV absorbing and non-UV absorbing compounds using a newly designed PDA-ELSD triggered preparative LC.