Matt Trass

Cannabinoids are successfully extracted from a complex brownie matrix using the QuEChERS sample preparation technique, significantly reducing the presence of matrix interferences. The resulting clean samples are analyzed by GC–MS using a specialized deactivated GC column to provide heightened peaks for the cannabinoid compounds.

Cannabinoids are successfully extracted from a complex brownie matrix using the QuEChERS sample preparation technique, significantly reducing the presence of matrix interferences. The resulting clean samples are analyzed by GC–MS using a specialized deactivated GC column to provide heightened peaks for the cannabinoid compounds.

Although gel permeation chromatography (GPC) is not as widely used as other chromatography methods, it continues to be a useful technique for analyzing the size and solution characteristics of organic polymers. In this study, GPC was applied to analyze different polar polymers that are commonly used in drug excipients. As a result of their polarity, some specialized operating conditions were required. Optimizing the separation brought to light many of the common parameters involved in optimizing GPC separations, and those are discussed in detail here.