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Analytical Instrumentation
Analytical Theory
Biological, Medical, and Clinical Analysis
Biopharmaceutical Perspectives
Biopharmaceuticals and Protein Analysis
Cannabis Analysis
Capillary Electrophoresis
Chiral Chromatography
ChromAcademy
Corporate Profiles
Data Acquisition, Handling, and Archiving
Data Analysis, Statistics, and Chemometrics
Dietary Supplements Analysis
Environmental Analysis
Field-Flow Fractionation (FFF)
Food and Beverage Analysis
Forensics, Narcotics
From the Editor
GC–MS
Gas Chromatography (GC)
HILIC
HPLC
Ion Chromatography
LCGC Interviews
LCGC TV: Gas Chromatography
LCGC TV: Hyphenated Techniques
LCGC TV: Liquid Chromatography
LCGC TV: Sample Preparation
LC–MS
Liquid Chromatography (LC/HPLC)
Market Profiles
Mass Spectrometry
Medical/Biological
Multidimensional GC
Multidimensional LC
Peer-Reviewed Articles
Pharmaceutical Analysis
Preparative-Scale Chromatography
Process Analytical Technology (PAT)
Quality Control/Quality Assurance (QA/QC)
Quality by Design (QbD)
Regulatory Standards, GLP and GMP Compliance
Sample Preparation
Size-Exclusion Chromatography (SEC)
Solid-Phase Extraction (SPE)
Supercritical Fluid Chromatography (SFC)
Supercritical Fluid Extraction (SFC)
The Next Generation
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Lori Lee Jessome

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Institute for Marine Biosciences, National Research Council, Hallifax, Nova Scotia, Canada.

Articles

Ion Suppression: A Major Concern in Mass Spectrometry

Ion Suppression: A Major Concern in Mass Spectrometry

Dietrich A. Volmer;Lori Lee Jessome
May 1st 2006

In this tutorial, the mechanism and origin of ion suppression will be investigated, as well as ways to validate the presence, and circumvent or compensate for, the effects in LC-MS.

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