Application Notes: General

Doxorubicin is a well-established chemotherapeutic agent frequently used in cancer treatment. Here we present the application of Electrical Asymmetrical Flow Field-Flow Fractionation (AF4) coupled with Multi Angle Light Scattering (MALS) to derive essential physico-chemical parameters, such as size distribution and surface charge, of a commercial liposomal Doxorubicin formulation.

Doxorubicin is a well-established chemotherapeutic agent frequently used in cancer treatment. Here we present the application of Electrical Asymmetrical Flow Field-Flow Fractionation (AF4) coupled with Multi Angle Light Scattering (MALS) to derive essential physico-chemical parameters, such as size distribution and surface charge, of a commercial liposomal Doxorubicin formulation.

• Automated HPLC modeling software can eliminate human error • Assessing the robustness of an analytical method • Getting a 360-degree view into the design space

Production of ethanol from biological sources produces side products, specifically propanol and methanol among other ketones, fatty acids, and esters.

Nine structurally-diverse, strongly basic drug compounds are resolved in less than 2 min using a high pH mobile phase and a fast acetonitrile gradient at 80 °C. 

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.

Meeting detection challenges presented by nitrosamine impurities Determination of NDMA and nitrosamine impurities using triple-quadrupole LC/MS Determination of genotoxic impurities in ranitidine APIs and drug products

This application note shows how to obtain a fast separation of cannabidiol and melatonin in a sleeping aid with excellent peak shapes using a YMC-Triart C18 column.

Antec Scientific ALEXYS FDG analyzer for seamless QC of the radiolabeled FDG and its by-products according to the European and US Pharmacopeia monographs.

SEC with multi-angle light scattering provides absolute characterization, in solution, of proteins, peptides, nucleic acids, polysaccharides, and bionanoparticles.

To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape in large molecule reversed-phase applications.

This application analyzes how to reduce peak widths by adjusting the flow rate for intact and reduced NIST mAb when using a bioZen WidePore C4 LC column.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection and separation of low-level impurities for subunit analysis.

Analyzing diverse method parameters, such as temperature, gradient program, and flow rates for optimization of intact mass applications when using bioZen WidePore C4.

Multiple C4 LC columns are compared to determine which provides the necessary separation of the impurity and avoids any spectral overlap in the MS detector.

bioZen WidePore C4 is built upon core-shell technology with bioinert hardware to offer optimal particle and pore-size morphology for high reproducibility and resolution.

Best practices with water in the analytical lab FAQs about lab water Lab water preparation optimized

To increase the resolution, this application evaluates and optimizes the gradient program when using a bioZen WidePore C4 LC column.

This technical overview describes the automated preparation of calibration solutions offered by the injector program available with Agilent autosamplers.

This technical overview describes the automated preparation of calibration solutions offered by the injector program available with Agilent autosamplers.