Application Notes: General

SEC with multi-angle light scattering (SEC-MALS) or in conjunction with a viscometer (SEC-MALS-IV) effectively characterizes branching in polymers.

FFF combined with NTA can be used in the development of therapeutics for biological samples for the optimization process in clinical trials under in vivo conditions.

SEC–MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg, and Rh, and how they are affected by formulation and storage conditions.

Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control of AAVs for gene therapy.

Light scattering facilitates vaccine development by enabling the analysis of size, shape, molar mass, and other parameters derived from these properties.

SEC-MALS is a platform method for effective product and process development, as well as quality control, of AAVs for gene therapy.

SEC–MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.

SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP: antibody interactions.

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retroviral viral vectors.

Field-flow fractionation with multi-angle and dynamic light scattering (FFF–MALS–DLS) combines size-based separation with absolute size and structure determination.

Light scattering quantifies key attributes of lipid nanoparticle gene vectors such as payload, size, titer, and stability in formulation and physiological media.

This brief communication highlights the assessment of Hamilton PRP-3 HPLC column attributes when analyzing biologically active peptides.

Cost-saving benefits are achieved through an automated workflow for mineral oil analysis in water by in-vial liquid-liquid extraction, clean-up, and on-line GC analysis

Multiclass-multianalyte method for mycotoxin testing in foods using immunoaffinity column sample clean-up with QSight LC–MS/MS

This application note is the first reported separation of Fluoxetine on polysaccharide-based chiral HPLC columns, and it comes on Daicel’s newest column, CHIRALPAK® IK.

This application note demonstrates pyrolysis–gas chromatography/mass spectrometry libraries for identification and quantification of microplastics.

This application note demonstrates how an affordable benchtop MALDI-TOF MS can be used to screen for liquid biomarkers for the diagnosis of melanoma.

A complete solution for the high-throughput, automated QC analysis of synthetic products using an affordable benchtop MALDI-TOF mass spectrometer and QC Reporter software.

This application shows an example of MALDI-TOF analysis for genotyping, using cystic fibrosis disease, and demonstrates the benefits of negative ion mode.

This application note showcases the ability of an affordable benchtop MALDI-TOF MS to efficiently measure various types of organic functional materials.

This article shows that the N-glycans of ACE2, a receptor of SARSCoV-2, and their sialic acid linkage types can be easily evaluated using MALDI-TOF analysis.

This application highlights a robust analytical method to pinpoint a common fraud affecting the olive oil industry: extra virgin olive oil adulteration with cheaper vegetable oils.

We present a solution for the characterization of a vitamin E-TPGS polymer sample using a benchtop linear MALDI-TOF MS with Polymerix polymer data analysis software.

Shown here, is a simple, fast way to obtain qualitative information on the azo colorant content of confectionery products for their safe use in the food industry.

Learn how this powerful tool that can handle many challenging analytical tasks

This case study demonstrates how method modernization is less difficult than the common perception, and good practices can be put in place to streamline the process.  

NIST mAb was analyzed using six different batches of 1.8 µm 200 Å dSEC-2 media packed with 150 mm length and 4.6 mm inner diameter columns.

Method development using standard phosphate containing buffers with different percentages of Isopropanol for aggregate analysis of an antibody-drug conjugate, Kadcyla.