Application Notes: General

SEC is highlighted as a tool for the separation and detection of higher-order structure of single stranded DNA oligonucleotides.

Review profiling of denatured and dissociated capsid proteins from AAV5 and AAV9, via analysis with LC-MS using a Biozen™ Intact XB-C8 reversed phase column.

This application note explains how the Mnova automation solution enables you to streamline reaction optimization process from raw data to results and decision-making.

In this application note, we will focus on scoring criteria and some important considerations for chromatographic method evaluation and selection.

Learn about Mnova Gears, a versatile platform for automating data analysis born out of the learning gained from developing solutions for many customers.

Expert insights on purification workflows in pharmaceutical labs, challenges in managing data and the role of data automation solutions in data analysis and integration

In this application note we outline some characteristics of automatable tasks on analytical data and give customer workflow examples to inspire your own ideas.

In this work we discuss an automatable sample preparation protocol for peptide mapping used in QC, bioprocess, analytical development, and research environments to deliver comprehensive information about the primary structure of biotherapeutic proteins.

In this work we discuss how to achieve complete and clean trypsin digestion with an enzyme that provides a balance of missed cleavage, non-specific cleavage, and trypsin autolysis.

In this work we discuss an automated high-throughput sample preparation method and fast LC-MS peptide mapping for Critical Quality Attribute (CQA) peptide measurement that was developed for low volume and low concentration microbioreactor samples.

This application note demonstrates how splitless micro-furnace pyrolysis increases the sensitivity of microplastic measurements.

Ultrapure water is essential for accurate analyses because as analytical methods become more sensitive, they also become more vulnerable to interference. Maintaining consistently high water quality is crucial for ensuring reproducible results and avoiding the need for time-consuming repeat analyses:

Air quality measurement: Continuous, cryogen-free on-line monitoring of PAMS in ambient air using hydrogen carrier gas using EPA PAMS method.

Tube-based thermal desorption for monitoring chemical warfare agents Malathion, Russian VX and mustard gas at ultratrace levels without degradation or losses.

This app note describes automated, high-performance GC–MS analysis of humid 'air toxics' samples in canisters, using a cryogen-free system for preconcentration and TD.

This application note shows the robust, reproducible analysis of trace VOCs in hydrogen fuel by TD–GC–MS/SCD.

Using thermal desorption–GC–MS is to address multiple challenges in the detection of microplastics in different salt samples.

This study investigates the performance of a high-throughput automated thermal desorption instrument coupled to GC–MS/MS for PFAS analysis.

This 9-minute acylcarnitines LC-MS/MS analysis allows testing of 25 underivatized acylcarnitines, including several isobaric compounds for differential diagnosis.

TD–GC–MS analysis of VOCs in air using H2 carrier gas meets all the performance criteria cited in US EPA Method TO-17, including linearity, reproducibility & MDLs.

Analysis of 15 most common sugars in honey within 25 min by HPAEC-PAD using Antec Scientific ALEXYS Carbohydrate Analyzer and SweetSep column.

Across the world, there has been an explosion of scientific discovery. Fueling this progress is a convergence of breakthroughs in biological sciences, automation, data harnessing, computing power, and software infrastructure. These are already driving changes in laboratory architecture, bringing automation and digitization to the fore to connect the physical and cultural attributes of laboratory space and scientific practice.

We present electrical asymmetrical flow field-flow fractionation with multi-angle light scattering (EAF4-MALS) to derive parameters of a liposomal form of doxorubicin.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

A separation of peptides is performed on a HALO 160 Å PCS C18 column showing excellent peak shape under formic acid conditions.

Discover the GC 2400™ Platform for consistent retention times and repeatable, precise sample injections.

Learn more about how the System Monitoring application provides real-time, contextual details for all Empower™ Software-controlled chromatography systems, helping you easily coordinate your laboratory work and respond dynamically to changing priorities.